PPARGC1A and myeloid sarcoma: In support of a protective potential of PGC-1α in EAE/MS, treatment of mice with resveratrol, a widely used inducer of its expression through the activation of Sirtuin 1 (SIRT1) [99], has been linked to clinical improvements in relapsing-remitting acute [130] as well as in chronic EAEs [131,132,133].