Other SIRT1 activating compounds or formulations have demonstrated beneficial effect on the spinal cord demyelinating lesions in EAE and in a virus-induced in vivo model of MS [135] and/or conferred protection against retinal ganglion cell (RGC) loss in EAE and virus-induced optic neuritis in rodents [130,131,135,136]. Here, SIRT1 is linked to myeloid sarcoma.