MBP and experimental autoimmune encephalomyelitis: The most widely used model is experimental autoimmune encephalomyelitis (EAE), which is an inflammatory and demyelinating autoimmune condition of rodents (predominantly mice), caused by an immune response against injected CNS myelin constituents, such as myelin basic protein (MBP), proteolipid protein, or myelin oligodendrocyte glycoprotein (MOG), or a passive transfer of cluster of differentiation 4-positive (CD4+) or cluster of differentiation 8-positive (CD8+) encephalitogenic T cells [1,2].