In addition, ligand activation of PPARγ stimulated oligodendrocyte differentiation from neural stem cells [70], promoted and accelerated the differentiation of oligodendrocyte progenitor cells in vitro with an additional increase in antioxidant defenses [71,72], and increased lipid production and terminal differentiation of cultured oligodendrocytes [73], together suggesting an additional possible protective role of PPARγ in MS as a mediator of remyelination. This evidence concerns the gene PPARG and myeloid sarcoma.