Transcriptional analyses have shown increased levels of mRNA-encoding CXCR3 and reduced levels of IFNγ, CCL3, CCL4, Granzyme B, and IL-10, in IFNγ/IL-17-co-producing CD4+ T cells sorted from the PBMC of untreated, relapsing MS patients versus age- and sex-matched healthy controls [94]. This evidence concerns the gene IFNG and myeloid sarcoma.