In a recent study, IFNγ/ GM-CSF expressing CD4+ T cells that express a mixture of Th1- and Th17-related molecules, (i.e., the chemokine receptors, CXCR3 and CCR6, and the transcription factors, RORγt and T-bet) were enriched in the cerebrospinal fluid and brain specimens of patients with MS [92]. Here, CD4 is linked to myeloid sarcoma.