In order to shed some light on the mechanism contributing to this phenomenon, we measured the levels of molecules belonging to the PI3K/AKT pathway in pcDNA- and GAB-transfected cells treated with H2O2; GAB negatively regulates this pathway in hepatocellular carcinoma cells [17], and the induction of the phosphorylation of AKT was previously observed upon H2O2 treatment in T98G cells [23]. This evidence concerns the gene AKT1 and hepatocellular carcinoma.