PHB1 and breast cancer: PHB protein and mRNA expressions have been found increased in gastric cancer tissues [119], esophageal squamous cell carcinoma [120], colorectal carcinoma tissues [121], human prostate cancer cells [122], high-grade breast cancer [123], human bladder cancer [124], papillary thyroid carcinomas [125], and hematologic tumor cells [126], and are risk factors for liver cancer [127,128].