PIK3CD and acute lymphoblastic leukemia: ZSTK-474 showed the highest cytotoxic effects when compared to both selective isoform inhibition (using the p110α inhibitor A-66, p110β inhibitor TGX-221, p110δ inhibitor CAL-101, and p110γ inhibitor AS-605240) and the dual p110γ/δ inhibition (using IPI-145) in T-ALL cell lines [79].