In this study, Ultimo et al. also showed that the pan-PI3K inhibitor ZSTK474, p110α inhibitor BYL719, and dual p110 γ/δ inhibitor IPI145, in combination with tyrosine kinase inhibitors, induced apoptosis in BCR-ABL positive B-ALL cell lines. The gene discussed is ABL1; the disease is acute lymphoblastic leukemia.