FLT3 and acute myeloid leukemia: Muranyi et al. showed that targeting integrin linked kinase (ILK) and FMS-like tyrosine kinase-3 (FLT3) with an inhibitor of ILK and FLT3, OLT0267, is cytotoxic to acute myeloid leukemia stem cells using a long-term suspension culture system and a NOD/SCID mouse leukemia-initiating assay [49].