After the evaluation of the primary network nodes and shared signaling pathways of potential targets of FZHY and liver fibrosis, we found that the affected signaling pathways of liver fibrosis treated by FZHY mainly include intracellular signaling in apoptosis, such as the PI3K-Akt, p53, TNF and MAPK-ERK pathways. This evidence concerns the gene AKT1 and Hepatic fibrosis.