For example, when endothelial cells were cultured in the presence of EPA incorporated in PC and PE, a significant reduction of the thrombin-induced intracellular release of AA metabolites and the thrombin-evoked release of endothelin-1 was observed, which is a vasoactive compound implicated in hypertension, atherosclerosis, and CVD [69]. The gene discussed is EDN1; the disease is hypertensive disorder.