While O-GlcNAcylation has been reported in some studies to impair the Akt phosphorylation, resulting in insulin resistance [106] and induction of apoptosis [107,108], studies in other settings report that the interplay between O-GlcNAc and Akt inhibits apoptosis and provide cytoprotection in the kidney [109] and the liver [110]. Here, AKT1 is linked to Insulin resistance.