These results suggest that decreased Ca2+ entry through SOCs and lower ER- Ca2+ levels, probably due to a failure of SOCE Ca2+ uptake caused by mislocalized mitochondria, may contribute to the pathogenesis of CMT patients carrying a recessive GDAP1 mutation inside the α-loop domain (Figure 1). The gene discussed is CISH; the disease is Charcot-Marie-Tooth disease.