We found a greater induction of autophagy markers, including an increased number of autophagy vacuoles, along with a significant decrease in the levels of mitophagy markers and inhibition of the PI3K-Akt/mTOR pathway by SLCP than by natural Cur in different GBM cell lines, without significantly affecting the rat glial tumor cells (C6-glioma) and mouse neuroblastoma (N2a) cells. This evidence concerns the gene AKT1 and glioma.