TNF and irritable bowel syndrome: Thus, high concentrations of Tumor necrosis factor (TNF-α), Interleukin-12 (IL-12), and Interleukin-6 (IL-6) are particularly destructive and are implicated in some of the pathologic responses that occur in endotoxic shock, in acute respiratory distress syndrome, and in chronic inflammatory diseases such as rheumatoid arthritis and inflammatory bowel disease (IBD) [2].