As with AgeAccelGrim, higher levels of age-adjusted DNAm PAI-1 are associated with hypertension status, type 2 diabetes status, time-to-CHD (Fig. 4), time-to-CHF, and early age at menopause (Supplementary Figs. 5-7 and 9), while lower levels are associated with disease free status (Stouffer P=2.9E-11, Supplementary Fig. 10) and better physical functioning (Stouffer P=1.4E-8, Supplementary Fig. 8). Here, SERPINE1 is linked to type 2 diabetes mellitus.