Similarly, time-to-congestive heart failure (CHF) is also associated with AgeAccelGrim (HR=1.10 and P=4.9E-9), age-adjusted DNAm cystatin C (HR=2.02 and P=2.0E-10) and DNAm PAI-1 (HR=1.58 and P=8.9E-10, Supplementary Fig. 5). The gene discussed is SERPINE1; the disease is congestive heart failure.