As other examples, virus inhibition of 5′-3′ exoribonuclease 1 (XRN1), a cellular exonuclease that degrades viral RNA, may promote replication of a flavivirus (e.g., dengue and Zika virus) coinfecting the same cell [35], and increased endothelial permeability during dengue virus infection may alter tissue tropism of coinfecting viruses [36]. The gene discussed is XRN1; the disease is dengue disease.