SLC4A4 overexpression impaired RCC cell proliferation, migration and invasion in vitro. Furthermore, forced expression of SLC4A4 reversed the effects of miR-223-3p on cell growth and migration in Cell Counting kit-8 (CCK-8) and Transwell assays by suppressing KRAS signaling. The gene discussed is KRAS; the disease is renal cell adenocarcinoma.