Our result was supported by the report that hypermethylation of the reelin gene provides a molecular basis for the reelin gene hypoactivity in schizophrenia.38 Interestingly, DNA hypomethylation restricted to the murine forebrain induces cortical degeneration and impairs postnatal neuronal maturation,39 which suggests that DNA hypomethylation can also be harmful. The gene discussed is RELN; the disease is schizophrenia.