Collectively, these data suggest that Nec‐1 can antagonize TNF‐α‐induced necroptosis in 16HBE cells with MUC1 downregulation and thus, furtherly support that MUC1 as a novel protective molecule in cell necroptosis on asthma through mediating the p‐RIPK1‐s166 expression. Here, PCSK1 is linked to asthma.