The phytoalexin resveratrol is a purported activator of SIRT1 and may also enhance the binding of SIRT1 to its activator lamin A (Liu et al. 2012), a protein closely tied to lifespan regulation since a splice site LMNA mutation results in Hutchinson-Gilford progeria (Eriksson et al. 2003). This evidence concerns the gene SIRT1 and Hutchinson-Gilford progeria syndrome.