Interestingly, TnV6 is reported to induce p21 expression, through a mechanism that requires SIRT2 but is independent of p53 (McCarthy et al. 2013); this induction of p21 may account for the proliferation arrest induced by TnV6 in cancer cells (van Leeuwen et al. 2012) accompanied by only low levels of apoptosis (Sunami et al. 2013). The gene discussed is TP53; the disease is cancer.