CEACAM5 and neoplasm: Using an rAAV expressing CEA antigen and a plasmid adjuvant encoding GM-CSF, we, for the first time to our knowledge, demonstrate the efficacy of an rAAV-CEA vaccine against a syngeneic, CEA-expressing, gastrointestinal cell line tumor in a CEA transgenic mouse model that constitutively expresses CEA in a spatiotemporal manner.