In addition, we showed that both BCL2L11 and PMAIP1 were downregulated by the tumor microenvironment in all the B-cell malignancies studied (MCL, FL, CLL, and SMZL), suggesting a fundamental role of these 2 specific BH3-only proteins in the microenvironment-dependent survival of lymphoma cells. Here, PMAIP1 is linked to B-cell chronic lymphocytic leukemia.