To gain insight into BCL2-family expression and regulation across most frequent mature B cell malignancies, we analyzed the BCL2-family expression in ten different hematological disorders i.e., MCL, BL, DLBCL, FL, B-cell prolymphocytic leukemia (BPLL), CLL, HCL, mucosa-associated lymphoid tissue (MALT), SMZL, MM, through normalization of Affymetrix Human Genome U133 Plus 2.0 public datasets. This evidence concerns the gene BCL2 and B-cell chronic lymphocytic leukemia.