We analyzed: (1) the common modulations across all B-cell neoplasms in comparison with their respective normal counterpart, (2) the modulations associated to the microenvironment and molecular subtypes, and (3) established a ratio of expression involving Bcl-2, Bcl-xL, Bax, and Bim that is associated with the response rate to venetoclax. This evidence concerns the gene BCL2 and B-cell neoplasm.