Considering the role of Z-disk as mediator of external mechanical stimulus, we chose several genes, encoding both structural and signaling Z-disk-associated proteins (Actn2, Ldb3, Cmya5, Fhl1, Fhl2, Csrp3, Nebl, Myoz2), to assess gene expression profiles under pressure overload conditions at different time points of LV hypertrophy development. The gene discussed is CMYA5; the disease is hypertrophy.