LDB3 and hypertrophy: Considering the role of Z-disk as mediator of external mechanical stimulus, we chose several genes, encoding both structural and signaling Z-disk-associated proteins (Actn2, Ldb3, Cmya5, Fhl1, Fhl2, Csrp3, Nebl, Myoz2), to assess gene expression profiles under pressure overload conditions at different time points of LV hypertrophy development.