PVR and autoimmune disease: As shown in Figure 3, PICALM, PVRL2, PVR, and CLU have shown to be related to systemic, an autoimmune disease characterized by vascular injury and debilitating tissue fibrosis (Xia et al., 2010; Ryu et al., 2014; Tsou et al., 2016; van Luijn et al., 2016).