In order to get insight into the IRF4 expression and its association with that of IRGs upon TNFα-blockade, as well as its potential relevance as a biomarker of therapy outcome, the IRF4 and IRGs expression was prospectively analyzed in a subgroup of 13 biological-naïve RA patients at baseline (BL) and after three months upon TNFα-blockade (post-treatment, PT). Here, IRF4 is linked to rheumatoid arthritis.