Exercise promotes increases in the systemic levels of anti-inflammatory cytokines such as Interleukin-4 (IL-4), Interleukin (IL-10) (Balducci et al., 2010) and adiponectin (Miyazaki et al., 2010), and stimulates the C-X-C motif chemokine ligand 8 (CXCL8), a cytokine that acts as an angiogenic factor in human microvascular endothelial cells (Ostrowski et al., 2001), and is associated with insulin resistance and obesity (Bruun et al., 2003). The gene discussed is ADIPOQ; the disease is obesity due to melanocortin 4 receptor deficiency.