In multiple cancers, stimulation of RET activity leads to changes in expression of transcription factors (e.g., SLUG, SNAIL, ZEB, TWIST), adhesion proteins (e.g., E-cadherin, N-cadherin, vimentin) and matrix remodeling proteins (e.g., matrix metalloproteases) that can cause cancer cells to take on more mesenchymal phenotypes (Melillo et al., 2005; Lian et al., 2017; Castellone and Melillo, 2018). This evidence concerns the gene RET and cancer.