RET and cancer: As part of a positive predictive multigene panel (e.g., ThyroSec v3, or ThyGenX/ThyraMIR), recognition of RET variants can help to distinguish benign lesions from cancer and identify cases requiring surgery (Sapio et al., 2007; Onenerk et al., 2017; Paschke et al., 2017; Steward et al., 2018).