Increased RET activity, mediated through NRTN or ARTN ligand complexes secreted by stromal cells, is detected in 60–70% of Acute Myeloid Leukemia (AML) cases with myelomonocytic differentiation, where it may promote cell viability and proliferation through suppression of autophagy by mTORC1-mediated signals (Gattei et al., 1997, 1998; Camos et al., 2006; Rudat et al., 2018). Here, NRTN is linked to acute myeloid leukemia.