RET chimeric oncoproteins are rare (0.2–0.5% cases), but promote tumor growth and migration in animal and cell based models (Gozgit et al., 2018) and have been correlated with worse prognosis, poor treatment response and reduced overall survival in colon adenocarcinoma patients (Le Rolle et al., 2015). The gene discussed is RET; the disease is colon adenocarcinoma.