In this context it will be interesting to: (1) know the differential expression of IL-6R in cardiomyocytes and in different subtypes of macrophages (2) investigate sources, spatial and temporal IL-6 concentrations, (3) distinguish between modifying enzymes and signaling pathways in specific cardiac regions, (4) understand the role of resident cardiac macrophages in the interplay between different cells in adipose tissues and how this may be affected in metabolic disorders. Here, IL6R is linked to metabolic disease.