Among them, sortilin is implicated in atherosclerosis and atherosclerotic plaques development through multiple processes, including regulation of calcification (Goettsch et al., 2016), lipoprotein metabolism (Kjolby et al., 2010; Strong et al., 2012), Glut4 biogenesis and glucose uptake in type-2 diabetes (Shi and Kandror, 2005) and arterial wall inflammation (Mortensen et al., 2014; Patel et al., 2015). This evidence concerns the gene SORT1 and atherosclerosis.