Among these 42 cases of DLBCL, 15 cases (35.71%, 15/42) were co-expressed with C-MYC and BCL-2 or BCL-6, 8 cases (19.05%, 8/42) were C-MYC and BCL-2 double positive expression, 7 patients (16.67%, 7/42) had C-MYC, BCL-2, and BCL-6 triple positive expression, and no cases of C-MYC and BCL-6 double expression were found. This evidence concerns the gene BCL6 and diffuse large B-cell lymphoma.