First, it was shown to be essential to the abnormal phosphorylation of the tau protein, the process believed to cause neurofibrillary tangles in Alzheimer’s disease (AD) (Hanger et al., 1992); thus, causing a surge in studies trying to identify the potential uses of pharmacological agents for the treatment of this disease (Beurel et al., 2015). The gene discussed is MAPT; the disease is Alzheimer disease.