We therefore believe that the PTVs identified in dominant DD genes in UKB are benign (Table 3) and are confident in refuting previous associations between haploinsufficiency in RNF135 and COL4A3 and dominant DD (note that this refutation has no bearing on the asserted relationship between the latter and either recessive DD or alternative mechanisms of disease). The gene discussed is RNF135; the disease is dentin dysplasia.