First, there was no association between a frameshift variant in the middle of COL4A3 (MIM: 120070)—where pathogenic variants are thought to cause a rare dominant form of Alport syndrome (MIM: 104200) (as well as benign familial hematuria [MIM: 141200])66, 67—and albumin creatinine ratios, hearing, or any of the development traits in UKB. This evidence concerns the gene COL4A3 and Alport syndrome.