The presence of multiple pathological lesions has implications for disease prognosis, and has been shown to alter the clinical phenotype; an elevated burden of hyperphosphorylated tau has been associated with a shorter survival time from the onset of dementia [128], and a summated score of hyperphosphorylated tau, Aβ, and α-syn is a better predictor of cognitive decline as measured by MMSE compared to individual pathology scores [129]. Here, MAPT is linked to dementia.