PTPN11 and ovarian carcinoma: Although a recent study revealed that activated Gab1 facilitates the activation of its downstream Shp2-Erk pathway to promote ovarian cancer metastasis [32], the present experiments showed that no significant change of phosphorylation of Erk is observed no matter whether Gab1 is overexpressed or knocked down, indicating that overexpression of Gab1 promotes BCa metastasis in an Erk activity-independent manner.