They found that persistent HIV-1 infection in humanized-mice led to induction of IFNs and ISGs including MX2, IFITM3, Trim22, ISG15, OAS1, and IFN regulatory factor 7 (IRF7) both in peripheral blood mononuclear cells (PBMCs) and in the spleen. Here, MX2 is linked to HIV-1 infection.