TNF and rheumatoid arthritis: However, in a set of patients treated with infliximab for rheumatoid arthritis, treatment induced an increase in interferon response genes including OAS1 and OAS2 in a subset of patients who had poor clinical response; [39] a subsequent study including patients on a variety of anti-TNF therapies including etanercept also found divergent responses in interferon profiles, though did not find an association with clinical response [40].