This agrees with other animal studies showing that sclerostin is unlikely to be involved in vascular mineralization.52, 64 No evidence suggests that sclerostin plays a causal role in cardiovascular disease, rather recent studies have reported an association between sclerostin levels and cardiovascular disorders.65, 66, 67, 68 The precise function of sclerostin in the regulation of the cardiovascular system remains to be defined. The gene discussed is SOST; the disease is cardiovascular disorder.