Statistical analysis revealed that increased HOXB7 expression resulted in significantly greater numbers of macroscopic lung metastatic cancer nodules in the mouse lung tissues (HOXB7 group, 149.5 ± 31.1; Vector group, 84.75 ± 17.6; Fig. 5i, P < 0.05). The gene discussed is HOXB7; the disease is metastatic malignant neoplasm.