Our analysis of canine oral melanomas, widely considered a model of human mucosal melanoma, revealed no KIT mutations, however, we identified NRAS (11%; 4 cases with Q61H/R/K, 3 cases with G12A/D), TP53 (8%; 5 different mutations in 5 cases), BRAF (3%; G457A, D582G), and KRAS mutations (5%; G12D/V, G13D) (Fig. 1 and Supplementary Data 2). This evidence concerns the gene KIT and mucosal melanoma.