The most prominent driver genes were NRAS (14%; 3 cases with Q61R, 1 case with G12A) and TP53 (14%, or 4 cases with 6 mutations; H54Y and P27S, R33W, R125W, and R158W and a deletion, g.50612732_50612735del, affecting a splice acceptor site), while two cases had mutations in BRAF (7%; V594E, and both P321L and S56L in vulvar tumor HD0021a). The gene discussed is NRAS; the disease is vulvar neoplasm.