Both, rs2168812 and rs3217870, have also been associated with cancer risk, similarly to the two TP53 variants, with the AKT3 variant rs12076373 (LDr2 with rs2168812 = 0.70) being related to risk for non-glioblastoma brain tumors34 and the CCND2 variant rs3217901 (LDr2 with rs3217870 = 0.63) being related to colorectal cancer (Supplementary Data 18). Here, AKT3 is linked to colorectal cancer.