We showed that although in basal conditions (i.e. in the absence of stress) the absence of Pyk2 does not modify the responses in anxiety-like and depression-like behavioral tests, PyK2 ablation in the adult confers a marked resistance to the sequelae induced by CUMS, as shown by the normal performances in the plus maze and sucrose preference tests. This evidence concerns the gene PTK2B and depressive symptom measurement.