MAP6 and schizophrenia: Interestingly, the microtubule system is also deficient in psychiatric diseases, such as schizophrenia, with NAP showing protection against cognitive deficits in two microtubule-associated mouse models of schizophrenia namely, the microtubule-associated protein 6 deficient (Map6+/−) mouse6, and the mutated disrupted in schizophrenia 1 (DISC1) mouse16.