PI4KAP1 and early-onset autosomal dominant Alzheimer disease: Despite the limited evidence regarding PI4KAP1, its parent gene, PI4KA, was implicated in late onset Alzheimer’s disease via its role in the synthesis of phosphatidylinositol phosphate57–59, which plays a diverse role in cell growth, differentiation and the nervous system60,61; whereas, the pseudogene PI4KAP2 was found to be dysregulated in Huntington’s disease62.