These findings suggested decreased ER export of GPI-APs, therefore we measured expression of known GPI-APs, including GPC1, NCAM, MDGA2 and EPHA 1, with and without the GPI-anchor post translational modification using Triton X-114 phase partitioning combined with PI-PLC treatment, and found that the anchored forms of GPC1 and NCAM had reduced sensitivity to PI-PLC treatment in schizophrenia. The gene discussed is GPC1; the disease is schizophrenia.