Lien et al. [18] reported that FSS (0.5, 6, and12 dyn/cm2) induced acidic vesicular organelle formation, microtubule-associated protein light chain 3 (LC3B) transformation and p62/SQSTM1 degradation in the HCC Hep3B cells, suggesting FSS induced autophagy in the HCC cells. The gene discussed is SQSTM1; the disease is hepatocellular carcinoma.