Moreover, the treatment of BDL-induced liver fibrosis with AICAR, activator of AMPK could inhibit the noncanonical NF-κB pathways as well as the related inflammatory response to protect the liver function, suggesting that AMPK is expected to become a new target for drug intervention for inflammatory-related liver disease and that AICAR may be a potential therapy to prevent liver injury from stress or inflammation. Here, NFKB1 is linked to Hepatic fibrosis.