A similar study reported that curcumin increased the expression of AMPK and diminished NF-κB protein in diabetic mice livers to relieve liver dysfunction [22], and it has been indicated that AICAR-induced activation of AMPK could ameliorate the hepatic steatosis and hypercholesterolemia associated with high TSH levels in patients with subclinical hypothyroidism [23]. This evidence concerns the gene NFKB1 and Hypercholesterolemia.