At a median follow-up of 15 months (range 1–68 months) and for the patients who had melanoma-specific overall survival data (n = 82) patients with high (>2+) nuclear plus cytoplasmic expression of SPEN by melanoma cells had longer melanoma-specific OS compared with patients with low expression (≤ 2+) (HR and 95CI, 0.56, 0.29–1.09, log-rank p-value 0.048) (Figure 9C). The gene discussed is SPEN; the disease is melanoma.