Additionally, the discovery of a regulatory role for IFITM3 in IL-6 production [43•], along with a recent report that IFITM3 is a negative feedback inhibitor of the type I IFN induction pathway [68], may suggest that IFITM3 is a broad regulator of inflammation and that it may play important roles in infections in which the balance between pathogen control versus tissue pathology is determined by these cytokines. This evidence concerns the gene IFITM3 and infection.