Genes participating in FGF-, IGF-signalling, hypoxia–response, CCKR-, chemokine- and cytokine-signalling pathways were overrepresented in the Asian population compared to Caucasians, while genes participating in Wnt-signalling, Alzheimer disease-, presenilin-, PDGF-, cadherin-, JAK/STAT- and GnRHR-signalling pathways were more heavily represented in the Caucasian cohort. Here, SOAT1 is linked to early-onset autosomal dominant Alzheimer disease.