These same authors analyzed RICTOR expression, and although they did not find an increased expression of this mTORC2 component between normal brain tissue and all grade astrocytoma, they observed nuclear localization of RICTOR in GBM that might suggest a change of its binding partner and a possible implication in tumor progression [53] (Table 1). The gene discussed is RICTOR; the disease is astrocytoma (excluding glioblastoma).