Indeed, Gini et al. proved that the mTOR kinase inhibitors CC214-1and CC214-2 (orally available) (Celgene Corporation (San Diego, U.S.A.)) are able to overcome the limitations of rapamycin and rapalogs and to inhibit GBM growth by blocking mTORC2 activity in vitro and in vivo, respectively [36, 37]; moreover, the same authors demonstrated that the sensitivity to CC214 compounds is significantly increased in the presence of EGFRvIII and PTEN loss and that the pharmacologic inhibition of autophagy induced by CC214 sensitizes GBM cells to cell death, preventing a cytostatic effect [37]. The gene discussed is PTEN; the disease is glioblastoma.