NFKB1 and glioblastoma: In this study, Tanaka et al. demonstrated that NF-κB signaling is upregulated in GBM cell lines and in GBM patients treated with rapamycin and that the inhibition of both mTORC1 and mTORC2 with the mTOR kinase inhibitor PP242 sensitizes EGFRvIII-mutant tumors to cisplatin-induced cell death, confirming the direct involvement of mTORC2 activation in chemotherapy resistance [31].