The 0.2 g/kg Cs-C-Q80 treatment only slightly downregulated the TNF-α and IL-1β, while 1.0 g/kg Cs-C-Q80 treatment significantly inhibited the TNF-α and IL-1β increasing (P<0.05), suggesting the involvement of the inflammation-resistant of Cs-C-Q80 treatment on vascular dementia. This evidence concerns the gene TNF and vascular dementia.