The NM23 isoforms (NM23-H1 or NM23-H2, also called NME1 or NME2) are heterogeneous in the process of metastasis of HCC; however, NME1 is recommended as one of immunohistochemical markers associated with biological properties of HCC in China. This evidence concerns the gene NME1 and hepatocellular carcinoma.