In addition, multivariate Cox proportional hazard regression model analysis demonstrated that PSORS1C1 SNPs rs541820233 and rs560052000 were associated with the OS and RFS of HCC patients, and heterozygous genotypes at these variants were associated with lower risk, implying that these SNPs may be independent prognostic indicators. The gene discussed is PSORS1C1; the disease is hepatocellular carcinoma.