This result agrees with the previous study by Colao et al. that enrolled a series of patients with ACTH-dependent CS, specifically evaluating thyroid function in patients treated for CS, and showed increased risk of developing autoimmune thyroiditis after therapeutic resolution of hypercortisolism, with rising positivity for specific antibodies and occurrence of thyroiditis in 60% of treated patients [9]. Here, POMC is linked to Cowden syndrome 1.